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The PACE Trial discredited

Recognition of the flaws in the PACE Trial has become more substantial as a result of David Tuller’s investigative reports on Virology Blog. Rebecca Goldin, a Prof of Mathematical Sciences, has produced a 7000 word critique  and Julie Rhmeyer has also written an essay – see below. James Coyne  has blogged at length and George Faulkner has produced a substantial report for The Centre for Welfare Reforms,  covering the role of the PACE Trial   –  “In the Expectation of Recovery” is downloadable at  http://bit.ly/expect-recovery. An editorial in The Centre for Welfare Reforms refers to the issues discussed and an open letter to the Lancet http://www.virology.ws/2016/02/10/open-letter-lancet-again/ is signed by 44 professors and other significant people in ME/CFS.

An Editorial in Stats.org  ( http://www.stats.org/editorial-on-pace/ ) explains the significance of what is at stake.  – “The PACE trial was “rigorously designed,” according to CNN, and it was published in one of the most prestigious medical journals, The Lancet, so its conclusions not only had the power to affect the way the condition was treated, they had the power to set the agenda for further research, potentially foreclosing other approaches.

As a result of PACE, the UK’s National Health Service, the Centers for Disease Control, the Mayo Clinic, and Kaiser all ended up recommending cognitive behavioral therapy and exercise for ME/CFS. There is now a PACE-like trial in children—MAGENTA. PACE has become the paradigm for understanding a condition affecting millions of people.”……

The editorial continues – “Because we believe that study design is a critical issue in science, and because statistics is central to understanding study design, we felt it was important to look at PACE from this perspective….

The conclusion of Rebecca Goldin’s 7,000-word analysis on PACE’s design is this: “The best we can glean from PACE is that study design is essential to good science, and the flaws in this design were enough to doom its results from the start.” http://www.stats.org/pace-research-sparked-patient-rebellion-challenged-medicine/   PACE: The research that sparked a patient rebellion and challenged medicine by Rebecca Goldin | Mar 21, 2016 Rebecca Goldin is Professor of Mathematical Sciences at George Mason University and Director of STATS.org

The editorial in Sense about Statistics explains of Julie Rehmeyer – “Julie Rehmeyer, has written  a powerful essay for our series “Epistemically Challenged” (over at Sense About Science USA) about her own experience of ME/CFS, and how it changed her view of science. As Rehmeyer is the most recent recipient of the American Statistical Association’s Excellence in Statistical Reporting Award (an honor we think Joseph Pulitzer would have considered equal to his eponymous prizes given his love of statistics), we took her criticism of PACE as another important alarm.”  http://www.senseaboutscienceusa.org/epistemically-challenged-julie-rehmeyer/

David Tuller’s articles on PACE

David Tuller’s numerous article on ME/CFS and the PACE Trial on Virology Blog are listed and linked to at   http://www.virology.ws/mecfs/

Chronic Fatigue Syndrome and the CDC: A Long, Tangled Tale

TRIAL BY ERROR: The Troubling Case of the PACE Chronic Fatigue Syndrome Study

TRIAL BY ERROR: The Troubling Case of the PACE Chronic Fatigue Syndrome Study (second installment)

TRIAL BY ERROR: The Troubling Case of the PACE Chronic Fatigue Syndrome Study (final installment)

PACE trial investigators respond to David Tuller

David Tuller responds to the PACE investigators

Trial By Error, Continued: Did the PACE Study Really Adopt a ‘Strict Criterion’ for Recovery?

Trial By Error, Continued: Why has the PACE Study’s “Sister Trial” been “Disappeared” and Forgotten?

An open letter to Dr. Richard Horton and The Lancet

Trial by error, Continued: PACE Team’s Work for Insurance Companies Is “Not Related” to PACE. Really?

A request for data from the PACE trial

Revisiting the PLoS One economics analysis of PACE

Trial By Error, Continued: Questions for Dr. White and his PACE Colleagues

Trial By Error, Continued: Did the PACE Trial Really Prove that Graded Exercise Is Safe? (with Julie Rehmeyer)

Trial By Error, Continued: More Nonsense from The Lancet Psychiatry

Trial By Error, Continued: A Few Words About “Harassment”

An Open Letter to the Lancet, Again